Dr. Daniah Beleford’s lab, within the Department of Physiology and Membrane Biology and the Department of Pediatrics at the University of California Davis, is recruiting for a postdoctoral scholar to participate in both basic and translational vascular biology research. Successful candidates will enjoy a supportive, diverse, and stimulating laboratory and departmental environment, filled with lots of collaboration, cutting-edge instrumentation and facilities, and a strong culture of training and mentorship.
The Beleford Lab studies underlying changes in molecular signaling that cause vascular malformations (abnormal development of blood vessels) in Hereditary Hemorrhagic Telangiectasia and other genetic vascular conditions. Hereditary Hemorrhagic Telangiectasia (HHT) is a rare Mendelian vascular condition that is characterized by arteriovenous malformations (AVMs), direct connections between arteries and veins without intervening capillary beds. It has previously been shown that single nucleotide polymorphisms within the genetic modifier PTPN14 (protein tyrosine phosphatase, nonreceptor, 14) associate with pulmonary AVMs in two large HHT cohorts. Our preliminary data suggest that the PTPN14 gene product binds and stabilizes BMP9 signaling components in endothelial cells, inhibiting ubiquitin-mediated protein turnover and promoting vascular stability. The Beleford Lab seeks to clarify the molecular interplay between PTPN14 and BMP9, TGFβ, and HIPPO signaling pathway components with the goal of understanding what causes the loss of vascular integrity in HHT and other severe vascular conditions in order to ultimately tailor targeted therapeutic interventions. Competitive applicants will be skilled in basic molecular and cell biology laboratory techniques as well as in mouse handling, crosses and care. The lab uses techniques such as DNA and protein electrophoresis, PCR, immunohisto- and cytochemistry, co-immunoprecipitation, proximity ligation assay.
Work/life balance: UC Davis is a supportive, diverse, and collaborative community, ideally situated in the sunny Sacramento Valley between beautiful Lake Tahoe for winter skiing and summer beaches, and the San Francisco Bay Area.
Salary: The posted UC salary scales set the minimum pay determined by rank and/or step at appointment. See Table 23: Postdoctoral Scholar-Employee, Postdoctoral Scholar-Fellow, Postdoctoral Scholar-Paid Direct, Fiscal Year. The salary range for this position is $64,480 – $69,342. “Off-scale salaries”, i.e., a salary that is higher than the published system-wide salary at the designated rank and step, are offered when necessary to meet competitive conditions, qualifications, and experience.
TO APPLY: Qualified candidates should email the following items to Dr. Daniah Beleford at email@example.com
Cover letter expressing your interest in the position
Minimum of 3 professional references (Name & Email Address)
We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, individuals’ with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct
Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain UC Davis positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check. More information is available at: http://www.uscis.gov/e-verify
As a condition of employment, you will be required to comply with the University of California SARS-CoV-2 (COVID-19) Vaccination Program Policy. All Covered Individuals under the policy must provide proof of Full Vaccination or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, and/or Religious Objection) or Deferral (based on pregnancy) no later than the applicable deadline. For new University of California employees, the applicable deadline is eight weeks after their first date of employment. (Capitalized terms in this paragraph are defined in the policy)
As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.
Qualifications: Applicants must have a PhD and/or MD, DO, MBBS degree and should have a demonstrated background in basic molecular and cell biology techniques as above. Additional training in basic genetics and genomics, including in the interpretation of genetic sequencing data, is helpful.
Successful applicants will be expected to stay abreast of current literature in the field, design and execute experiments, assist in the collection of data for grant applications, and to prepare their results for presentation at national and international scientific conferences and for publication in peer-reviewed journals. Successful applicants will also be expected to mentor graduate and undergraduate students, including hands-on teaching at the bench and in the vivarium. The ability to work independently with minimal supervision is also crucial.
About Department of Physiology and Membrane Biology
A Research PowerhouseIn addition to UC Davis School of Medicine’s top 10 national rankings for student diversity, family medicine and primary care, it is among the country’s leading medical schools for transdisciplinary research. In 2022-23, our medical school’s trailblazing research teams achieved a record-high $401 million, contributing substantially to the more than $1 billion in external research funding achieved by UC Davis overall. We’re also ranked 32nd among the nation’s leading medical schools for National Institutes of Health (NIH) funding.